PRS-powered disease risk reporting
We’ve previously written about how you can use Allelica’s DISCOVER software to build new polygenic risk scores (PRS) and to deploy them at scale with PREDICT. While a PRS provides ... Read more →
Harnessing the power of PRS by combining standardized reporting with Allelica’s software
This week, scientists from the Clinical Genome Resource (ClinGen) Complex Disease Working Group and the Polygenic Score (PGS) Catalog published a paper in Nature introducing... Read more →
Understanding the link between genetics, cholesterol and coronary artery disease
Cardiovascular disease is the leading cause of death worldwide, with recent estimates putting the global death toll at around 18 million each year. It is also a major burden on populations and health systems, contributing to... Read more →
The PREDICT Module: Unlocking the power of genomics
In our previous articles on Allelica’s PRS pipeline, we ran through how you can use our DISCOVER module to build your own PRS for a disease or trait of interest, as well as how our VALIDATE module can be used to test the predictive power of... Read more →
The VALIDATE module: Quantifying the power of PRS
Essential testing of your PRS on an independent population. In our previous articles outlining Allelica’s PRS pipeline we described how users can impute genotype or... Read more →
The DISCOVER Module: Seamlessly building new polygenic risk scores
A user friendly, cloud-based computing solution to build state-of-the-art, publication ready polygenic risk scores. The DISCOVER moduleallows users to build their own polygenic risk... Read more →
The IMPUTE Module: Enriching Low-Coverage and Microarray data
Fast and scalable genome imputation of Low-Coverage WGS and Microarray data in just minutes. Allelica’s PRS pipeline is built around a set of interconnected modules... Read more →
Coronary Artery Disease: Predicting risk through genetics
Within the last two decades, and upon completion of the world’s largest biological project in 2003, interest in the human genome and its effect on... Read more →
Large Scale Genomics Datasets In the UK
We previously wrote about the enormous impact that the UK Biobank (UKBB) is having to translational research. Although the scientific outputs from this project are now beginning... Read more →
Genetics is actionable
In Allelica we’re very excited about the incredible advances that analyses of large DNA datasets are bringing to medicine. In addition to the increasingly... Read more →
Beyond BRCA
Vast quantities of human DNA have been sequenced for biomedical research and clinicians, researchers and innovators are now beginning to focus on the next phase... Read more →
Disease is Polygenic
In the late 19th Century, a Moravian monk named Gregor Mendel passed his time by running experiments cross-breeding different types of pea plant. Amongst his... Read more →